Pharmacologic diuresis is safer than ultrafiltration for cardiorenal syndrome

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Pharmacologic diuresis is safer than ultrafiltration for cardiorenal syndrome

A critical appraisal and clinical application of Bart BA, Goldsmith SR, Lee KL, et al. Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N. Engl. J. Med. 2012;367:2296-2304. doi: 10.1056/NEJMoa1210357

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Reconsidering ultrafiltration in the acute cardiorenal syndrome.

Aggressive diuretic therapy in a patient who is hospitalized for acute decompensated heart failure often leads to progressive renal dysfunction despite persistent congestion. The underlying mechanisms of this so-called acute cardiorenal syndrome are complex and not fully understood.1,2 As initial therapy in this setting, ultrafiltration as compared with diuretic therapy may result in a higher r...

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Cardiorenal syndrome: ultrafiltration therapy for heart failure--trials and tribulations.

Heart failure remains the leading cause of hospitalization in older patients and is considered a growing public health problem with a significant financial burden on the health care system. The suboptimal efficacy and safety profile of diuretic-based therapeutic regimens coupled with unsatisfactory results of the studies on novel pharmacologic agents have positioned ultrafiltration on the foref...

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Ultrafiltration in decompensated heart failure with cardiorenal syndrome.

BACKGROUND Ultrafiltration is an alternative strategy to diuretic therapy for the treatment of patients with acute decompensated heart failure. Little is known about the efficacy and safety of ultrafiltration in patients with acute decompensated heart failure complicated by persistent congestion and worsened renal function. METHODS We randomly assigned a total of 188 patients with acute decom...

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Cardiorenal syndrome: new developments in the understanding and pharmacologic management.

Cardiorenal syndromes (CRSs) with bidirectional heart-kidney signaling are increasingly being recognized for their association with increased morbidity and mortality. In acute CRS, recognition of the importance of worsening kidney function complicating management of acute decompensated heart failure has led to the examination of this specific outcome in the context of acute heart failure clinic...

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ژورنال

عنوان ژورنال: Clinical Research in Practice: The Journal of Team Hippocrates

سال: 2016

ISSN: 2379-4550

DOI: 10.22237/crp/1472046944